The cholesterol transporter ABCA1 is a serpentine protein that is woven through the cell membrane. Control of cholesterol uptake and release is essential for maintaining the correct levels in the blood and tissue. The locations of the 10 SNPs that cause amino acid changes are shown.
Source: Clee, S.M. et al. Common genetic variation in ABCA1 is associated with altered lipoprotein levels and a modified risk for coronary artery disease. Circulation 103, 1198-1205 (March 6, 2001).