Comparison of differentially expressed genes in DTH, tape strip, and psoriasis samples. Total RNA was prepared from affected and unaffected skin of three patients following tapestripping and three patients following induction of a DTH reaction and analyzed on oligonucleotide arrays containing 7000 full length human genes. Genes differentially regulated by two-fold or greater between uninvolved and lesional psoriasis skin, normal and DTH skin and normal and tape-stripped skin are presented. (a) Venn diagram comparing the overlap in differential gene expression between the various sample types. (b) Histograms of 13 genes differentially regulated following a DTH reaction, tape stripping (TS) and in psoriasis lesions. (c) Histograms of 23 genes differentially regulated following a DTH reaction and in psoriasis lesions. (d) Histograms of 30 genes differentially regulated following tape stripping and in psoriasis lesions. Data are graphed as fold change and are color coded according to the average frequency value. Average fold change values are depicted at the end of the histograms. Histograms are color coded according to the average frequency value. Gene names and accession numbers are provided.
©2002 The Pharmacogenomics Journal