Evolutionary relationships between KRABA-containing ZNF genes in HSA19 and related mouse regions. (A) An evolutionary tree showing relationships between KRAB-encoding motif nucleotide sequences of a representative set of 101 mouse and 160 human ZNF genes was estimated with the PHYLIP tree generating program. Only mouse KRAB sequences that were well anchored to specific positions in the comparative map were analyzed. Information regarding the sequences used to generate the tree is summarized in Web tables D and E. Mouse genes are represented by colored circles and human genes are denoted by arrowheads; symbol colors representing each gene's cluster location in HSA19 and related mouse DNA, as indicated by colored arrows on either side of the HSA19 ideotype, in (B). Unfilled black symbols represent singleton ZNF genes. (B) Approximate positions of ZNF clusters Z1-Z11 relative to the HSA19 map, as summarized in Table 2. Arrows at left of the chromosome figure show positions of human clusters, color-coded to correspond to symbols representing resident genes on the evolutionary tree, in (A). Double arrows point to large clusters comprising genes distributed over distances of >1 Mb. Arrows at right of the figure show the relative position of mouse clusters in related homology segments; mouse clusters Z6 and Z7 were not sequenced.
Dehal, P. et al. Human chromosome 19 and related regions in mouse: Conservative and lineage-specific evolution. Science 293, 104-111 (July 6, 2001).