Overview of metabolism and transport in S. pneumoniae. Pathways for energy production, metabolism of organic compounds, and capsule biosynthesis are shown. There exist other genes in the capsule biosynthesis locus to which no specific function could be assigned. Transporters are grouped by substrate specificity as follows: inorganic cations (green), inorganic anions (pink), carbohydrates/carboxylates (yellow), amino acids/peptides/amines/purines and pyrimidines (red), and drug efflux and other (black). Question marks indicate uncertainty about the substrate transported. Export or import of solutes is designated by the direction of the arrow through the transporter. The energy-coupling mechanisms of the transporters are also shown: Solutes transported by channel proteins are shown with a double-headed arrow; secondary transporters are shown with two arrowed lines, indicating both the solute and the coupling ion; ATP-driven transporters are indicated by the ATP hydrolysis reaction; and transporters with an unknown energy coupling mechanism are shown with only a single arrow. Components of transporter systems that function as multisubunit complexes that were not identified are outlined with dotted lines. Where multiple homologous transporters with similar substrate predictions exist, the number of that type of transporter is indicated in parentheses. Systematic gene numbers (SPxxxx) are indicated next to each pathway or transporter; those separated by a dash represent a range of consecutive genes. Details for the PTS transporters are indicated in Web fig. 4 (9). Abbreviations are as follows: ADP, adenosine diphosphate; UMP, uridine monophosphate; UDP, uridine diphosphate; FucNAc, N-acetylfuco-samine; Gal, galactose; GalNAc, N-acetylgalactosamine; GluNAc, N-acetylglucosamine; ManNAc, N-acetylmannosamine; NeurNAc, N-acetylneuraminate; P, phosphate; PP, diphosphate; Pyr, pyruvate.

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