Regional retinal disease gradient in canine and human RHO mutations. (a) Superimposed drawings of ophthalmoscopically evident lesions in one eye each from four RHO mutant dogs (displayed as left eyes) illustrate the range of topographic variation in disease. Darker grays represent higher frequencies of overlap of lesions among eyes. Lesions are drawn superimposed on a schematic of the dog fundus; green outlines tapetal area; red are blood vessels; white circle is the ONH. (b) OCT LRPs from an 8-mm-long horizontal scan located ~3.3 mm superior to the ONH for a normal dog and right eye of an RHO T4R mutant dog; arrow is region from which LRPs are derived. For the normal dog, retinal thickness is the same throughout the length of the scan; the mutant dog shows distinct regions of thinning. (c) Topographical maps of retinal thickness in the left eyes of normal and RHO T4R /+ mutant dogs. Avery small focus of retinal thinning in the 6-mo-old dog and a larger area of thinning in the 13-mo-old mutant dog are apparent in the superior temporal quadrants. (d) Kinetic visual field showing an altitudinal defect in a patient with adRP caused by an RHO G106R mutation. (e) LRPs derived from scans from the region indicated by the arrow on the visual field. The retina becomes progressively thinner as the scan moves toward the region of dysfunction.

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