Concordance between DNA copy number and gene expression across chromosome 17. DNA copy number alteration (Upper) and mRNA levels (Lower) are illustrated for breast cancer cell lines and tumors. Breast cancer cell lines and tumors are separately ordered by hierarchical clustering in the Upper, and the identical sample order is maintained in the Lower. The 354 genes present on the microarrays and mapping to chromosome 17, and for which both DNA copy number and mRNA levels were determined, are ordered by position along the chromosome; selected genes are indicated in color-coded text. Fluorescence ratios (test/reference) are depicted by separate log2 pseudocolor scales (indicated).
©2002 National Academy of Sciences, U.S.A.