Histograms with tumor-normal ratios (logarithm to base 10) for two genes. (A) fibronectin1, (B) metallothionein 1G. The bars in the histograms are colored by patient. In most cases, four ratios were measured for each patient. The four subpanels correspond to different tumor stages, stage I, III, and IV primary tumors, and metastases (M). The histograms show systematic trends. (A) Up-regulation,(B) down-regulation, interindividual variations (different-color patches within a histogram), and experimental noise (distribution of same-color patches). The vertical bars indicate ratios of 1/3.5 and 3.5.

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