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A new map of SNPs in the fly
  
By
Edward R. Winstead


 

Scientists have developed a new map of single nucleotide polymorphisms, or SNPs, in the fruit fly genome. The map identifies nearly 800 locations where two widely used laboratory strains differ slightly in their DNA. Like the Drosophila genome sequence, the SNP map is a tool for pinpointing fly genes and mutations that are relevant to human medicine.


Detail from fly SNP map. View larger

Barry J. Dickson, of the Research Institute of Molecular Pathology in Vienna, Austria, and colleagues created the map. They compared the DNA of two strains and found more than 7,000 SNPs and 1,300 other genetic variations. These were consolidated into 787 markers throughout the Drosophila genome.

"The identification of sequence polymorphisms in the Drosophila genome will make it possible to map mutations directly to the genome sequence with high accuracy and resolution," the researchers write in Nature Genetics. In conjunction with other mapping methods being developed, they add, "our SNP map should now allow high-throughput, high-resolution genetic mapping in Drosophila."

Another map of SNPs in the fly was published in June. Roger A. Hoskins, of Lawrence Berkeley National Laboratory, in Berkeley, California, and colleagues identified 474 markers throughout the genome using standard laboratory strains. The map appeared in Genome Research.

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Berger, J. et al. Genetic mapping with SNP markers in Drosophila. Nat Genet 29, 475-481 (December 2001).
 
Hoskins, R.A. et al. Single nucleotide polymorphism markers for genetic mapping in Drosophila melanogaster. Genome Res 11, 1100-1113 (June 2001).
 

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