GNN - Main Archive 2001

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2000

December 21, 2001

The Genome of Agrobacterium tumefaciens:
A plant pathogen with a talent for transferring genes

Finished sequence of human chromosome 20

The miniature genome of Oikopleura dioica

New map of the zebrafish genome

How a parasite changes its molecular coat

Using molecular tools to diagnose cancer

Antibiotics from a microbe: The genome of an industrial organism

Two studies on schizophrenia and motion perception

Fighting crown gall disease

Poinsettias for the Holidays

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December 7, 2001

Genes and Parkinson’s:
Recent findings hint at genetic role in Parkinson’s in older patients

SNP survey finds surprising similarity in humans worldwide

A new map of SNPs in the fly

New type of leukemia identified

Genetic mutation protects against malaria

Space and cancer agencies collaborate on nanoscale sensors

Reduced and specialized: The genome of the parasite E. cuniculi

Standards proposed for gene expression data

Targeting microbes

Mosquitoes of Southeastern Australia

Artistic insights into the life sciences

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November 23, 2001

Mapping the Dog:
What the human genome sequence can do for dogs. And vice versa.

Cody Bear and New York City's Faithful:
Rescue dog affected by September 11 trauma

Testing hypotheses about genes using genomic and proteomic data

RESOURCERER: A resource database for DNA microarrays

Sulfolobus tokodaii: A genome from Japan

Two imprinted genes identified using DNA microarrays

DNA microarrays used to profile kidney cancer

A reference for the human genome: The Tetraodon pufferfish sequence

Dictyostelium discoideum

Dictyostelium : A model system in motion

Tetraodon: A pufferfish aquarium

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November 9, 2001

Watching Genomes Work:
A technology called TraSH asks, What do all these genes do?

Scientists define structures Salmonella use to invade cells

A lean model genome: The Japanese pufferfish is sequenced

New sequencing strategy details repetitive structures linked to infertility

The amount of gray matter matters:
Brain maps reveal how genetic differences influence brain structure

An automated system for classifying related proteins by structure

Modified tomato plants silence the genes of invaders

Gene candidate mapped for late-onset Parkinson's disease

Mitochondrial genomes of animals

Genetic Maps of Brain Structure by Paul Thompson

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October 26, 2001

Genes on Alert:
Genomics and the Fight Against Infection

Structures and targets of the anthrax bacterium

Heat resistant: The P. fumarii genome is sequenced

Insights into genome evolution: The sequence of Rickettsia conorii

Two sequenced Salmonella genomes

New model of Huntington's disease

New gene identified for inherited form of ALS

Genetics in the olive grove

Using human DNA sequence, scientists identify mutation for cattle disease

More on Anthrax

Exploring Molecular Worlds by Hunter O'Reilly

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October 12, 2001

Targeted Drug Discovery:
A novel screen for potential cancer drugs

From stomach bug to blood-borne pathogen:
The genome sequence of the plague bacterium

Streptococcus pneumoniae strain R6 is sequenced

Endangered wild sheep clone reported to be healthy

Carrier screening for cystic fibrosis offered

What's missing: New software analyzes genomes

The Geology of Biology:Genome-inspired art in London

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September 28, 2001

The Big Picture:
Optical maps guide shotgun sequencing from start to finish

Mountains of data: A three-dimensional C. elegans gene expression map

Human imprinted gene lies within non-imprinted gene

Transgenic white clover as oral vaccine against shipping fever

Chromosome 'capping': Study finds differences in human telomeres

Stress worsens stroke outcome by affecting gene expression

Genomics is News

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August 20, 2001

The Success Story of Gene Tests :
After 30 years, the Tay-Sachs screening program has lessons to share

Genomewide screen for autism points to chromosomes 2, 7, and 16

Hunting for bipolar genes in patients who respond to lithium

Researchers identify major freckle gene

Genome scans for type 2 diabetes confirm potential hotspot

Catalase SNP linked to blood pressure

Tay-Sachs screening

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August 6, 2001

Building a Better Gene Trap:
Researchers improve technique for large-scale studies of gene function in mice

In symbiosis with alfalfa: The complex genome sequence of Sinorhizobium meliloti

‘Arrays of arrays’ promise more efficient gene expression profiles

Yeast proteome microarray developed

A repeated case: Expansions in RNA cause myotonic dystrophy

Genetic diversity in maize: SNP survey of chromosome 1

Trapping Genes

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July 23, 2001

Sugar Transporters and Foreign DNA:
The sequenced Streptococcus pneumoniae genome

Mycoplasma pulmonis: The genome of a minimalist

Profiling gene expression in the mouse hippocampus

DNA microarrays used to compare strains of Staphylococcus aureus

Banana genome in five years

SNPs in the IGF2 gene are associated with body weight in adults

New tools, old pathogen

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July 9, 2001

Trafficking in Cholesterol: Investigating the Human ABCA1 Gene

Life at very high temperatures: The genome of Sulfolobus solfataricus is sequenced

Listeria genome sequence as basis for improving food safety

Evolutionary forces in the human and mouse genomes:
Researchers compare human chromosome 19 and related regions in the mouse

Predicting gene function based on fusion events

Out of the loop: New evidence for the complexity of biological clocks in mice

Tangier disease

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June 25, 2001

Setting the Record Straight :
Two studies find no evidence that humans have acquired genes directly from bacteria

Early view of the Porphyromonas gingivalis genome

New evidence for Alzheimer's gene on chromosome 10

DNA microarrays used to investigate how proteins bind DNA

Using E. coli gene arrays to explore genome of the tsetse fly microbe Wigglesworthia glossinidia

Cross-species transmission of prion disease: A study of factors influencing incubation periods in mice

Evolution and genomics

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June 11, 2001

The Homophila Database: Screening the Fly Genome for Human Disease Genes

Mutations in SH3BP2 cause cherubism

Small study shows non-viral gene therapy for hemophilia A is safe

Classifying cancers with DNA microarrays and artificial neural networks

Common mutations of the PTEN gene are linked to earliest stages of endometrial cancer

No evidence for the ‘horizontal’ transfer of genes from bacteria to humans

The power of Drosophila genetics

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June 4, 2001

The Bone Builders:
Scientists are developing stem cell and gene therapies to repair fractures and treat bone loss

Mutations in the keratin 8 gene linked to liver disease

Genome screens for asthma:
Researchers consider multiple susceptibility factors simultaneously

Gene variants accelerate progression to AIDS

Beyond polymorphisms: Genome scans and prion disease in mice

Genes, scaffolds and cells for bone repair

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May 28, 2001

Streams of Data: Scientists are using DNA sequencers in efforts to conserve species of Pacific salmon

Researchers transform tomato with Petunia gene

Researchers annotate mouse microarray used in studies of early development

Acquiring oncogenes through horizontal transfer

Mutations in the human gD crystallin gene trigger cataract formation

Variant of agouti-related protein linked to anorexia nervosa

Saving salmon

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May 21, 2001

Researchers Challenge Recent Claim That Humans Acquired 223 Bacterial Genes During Evolution

Gene therapy researchers repair rather than replace damaged genes

Gene therapy may protect donated organs from injury

Polymorphisms in clotting factors

A SNP in the prohibitin gene may modify breast cancer susceptibility

Lateral gene transfer

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May 14, 2001

Beyond Insomnia: Strategies of Circadian Genomics

Genetic evidence suggests European migrants may have influenced the origins of India's caste system

Borrowing from bacteria: Incorporating an E. coli gene into pigs could reduce the environmental impact of swine production

The glycome project:
A sugar-coated proposal

Microarrays reveal differences among types of primary pulmonary hypertension

Study shows thrombomodulin variation associated with increased risk for heart disease in African Americans

Circadian rhythms and human medicine

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May 7, 2001

The Legacy of Solid Gold:
Comparing human and sheep genomic sequences reveals six imprinted genes at the callipyge locus

How to build a kidney

Genome screen for rheumatoid arthritis:
More evidence of shared risk factors with other autoimmune diseases

Identifying disease-causing nonsense mutations throughout the genome

Gene therapy rescues nerve degeneration in diabetic rats and rabbits

New assay identifies SNPs in the MDR1 gene: implications for individualized drug therapies

Genomic imprinting

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April 30, 2001

On the Trail of Anxious Mice:
Mouse data provide targets for genome screens in human anxiety disorders

Gene therapy restores vision in blind dogs

Sequence of the human CYP3A locus: Genetic variability and drug responsiveness

Transforming a bacterial protein into a zinc 'biosensor'

The role of the MUC 1 mucin gene in infertility

Variations in the penA gene of Neisseria meningitidis increases penicillin resistance

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April 23, 2001

Snapshots of Genomic Evolution:
Microarrays reveal an ancient pathogen adapting to life in San Francisco

In search of the sweet-tooth gene

French scientists sequence the genome of a bacterium vital for cheese production

Genomes of two drug-resistant Staphylococcus aureus strains are sequenced

Mapping a cancer hotspot in the rat genome

Polymorphisms in DNA repair gene XPD may increase risk of skin cancer

Microarrays and comparative genomics

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April 16, 2001

New Clues: Could Viruses or Myelin, the Fatty Insulation Surrounding Nerves, Play a Role in Schizophrenia?

Genome sequence of Streptococcus pyogenes, the flesh-eating bacterium

First tests to use gene therapy for rheumatoid arthritis show it to be safe

Men have biological clocks too: Father's age linked to risk of schizophrenia

Gene variant affecting metabolism cuts risk of childhood leukemias

Narcolepsy may be caused by a mutation in the prepro-orexin gene

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April 9, 2001

We Are Not Alone: Harnessing the Invisible World of Microbes Within Us:
New approach to gene therapy uses symbiotic microbes to deliver genes

Converting Symbiotic Microbes into Vaccine Vectors

Sexuality and the C. albicans sequence:
Genomic evidence for a complete sexual cycle in the pathogen Candida albicans

Variant of a collagen gene affects bone strength, correlates to fracture risk

New framework map of the rat genome

Variant of the angiotensin II type 2 receptor gene alters heart structure

Microarrays reveal patterns of Y chromosome variation

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March 26, 2001

The Fly’s Sensational Sequence:
Columbia University and Celera researchers use bioinformatics and genomics to uncover taste receptors in Drosophila

New role for the APC gene in chromosome segregation and stability

Gene expression in regenerating sea stars

Genome sequence of the bacterium Caulobacter crescentus

The a globin gene cluster:
Comparing human, chicken, mouse, and pufferfish sequences

cSNP analysis of the ABCA1 gene: Common variant lowers risk for coronary artery disease

GNN Genomes:
A Selection of Sequenced Organisms 2000-2001

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March 19, 2001

Test Case for Genetic Testing:
Population-based screening for cystic fibrosis mutations is coming. Are we ready?

Directed evolution predicts antibiotic resistance

Toward global gene expression profiles: The RIKEN '19K' mouse arrays

Microarrays identify strain-specific features of Helicobacter pylori that influence stomach inflammation

Recommendations for population-based cystic fibrosis carrier screening

Gene variant of the androgen receptor associated with male pattern baldness

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March 12, 2001

Toxic Triggers: Genes, Pesticides, and Parkinson's Disease

Genome sequence of Pasteurella multocida

"The Trials and Triumphs of Gene Therapy":
A talk by Inder Verma at Washington University School of Medicine

Target genes for antifungal drugs

Scientists identify four genes associated with brain cancer

Serotonin and the seasons:
Polymorphism in 5-HT2A receptor gene is associated with seasonal depression

Deafness in the literature

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March 5, 2001

Between Genes and Proteins:
After DNA, scientists face the complex world of RNA

Optical imaging of blood vessel formation in live mice:
New model for testing angiogenesis inhibitors

Gene therapy reduces cancer in knockout mouse model:
Stomach cancer in mice responds to doses of human tumor-suppressor gene

Scientists use targeted methylation and microarrays to map locations of DNA binding proteins

Novel human clotting factor identified:
Human gene resembles mouse counterpart linked to miscarriages and transplant rejection

cSNPs on chromosome 21

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February 26, 2001

A Theme among Brain Diseases:
'Stuttering' genes can lead to the loss of nerve cells in the brain and spinal cord

Huntington's Researchers Get a New Mouse:
Mice have symptoms of neurological disease; Huntington gene has 150 DNA repeats

Genomics of salt-induced hypertension:
Researchers identify chromosome regions of interest in mice, humans, and rats

Effects of gene therapy seen in aging monkeys:
Shrinking neurons respond to injections of human growth factor

Genome of bacterium that causes leprosy is sequenced

Genes that respond to fatty diet may portend obesity

Mutation in the SCN5A sodium-channel gene slows heart rate

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February 12, 2001

One Gene, Many Proteins:
Ultimately it will be necessary to measure mRNA in specific cell types to demonstrate the presence of a gene

Genomes, Proteomes, and Medicine:
Opportunities in Medical Science in the 21st Century

Whose genome is it anyway?

The landscape of the genome: deserts, islands and oases

Making predictions about the proteome:
Using fly and worm data, computers classify human proteins by function

Don't despair. You have at least twice as many genes as a fruit fly.

Sizing up genomes: Amoeba is king
Reasons for the size of a genome and the number of genes are not clear

A little variation is the spice of life: SNPs

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February 2, 2001

Paranoid but Popular:
Mutant mouse-ear cress offers insight into natural plant resistance

Region of chromosome 22 linked to bipolar disorder, again:
Same region may contain susceptibility gene(s) for schizophrenia

New gene linked to juvenile diabetes

Scientists identify susceptibility gene for prostate cancer on chromosome 17

A new animal model for prostate cancer

Genetic marker found for severe ulcerative colitis

The Promise of Muta-genomics:
Joseph H. Nadeau considers the feasibility of developing large-scale mouse mutagenesis surveys

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January 26, 2001

A Fatal Flaw in the Hearts of Children:
Scientists identify a gene involved in the sudden cardiac deaths of healthy children

Mosaic blood vessels:
Implications for drug delivery, metastasis and cancer therapy

Another use for jellyfish gene:
Tracking the spread of cancer

Resisting insulin:
A new hormone may be the link between obesity and type II diabetes

Researchers sequence strain of E. coli linked to disease:
Bacterial genome is compared to that of a harmless laboratory strain

Creutzfeldt-Jakob disease and mental illness:
Mutations in the prion gene are not associated with schizophrenia in Taiwanese population

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January 16, 2001

Many Questions, Multiple Choices:
A Survey of GeneticTesting in the Real World

Introducing ANDi: The first genetically modified monkey

Estrogen in the male brain:
Sexual behavior is abolished in male mice without estrogen-receptor genes

Investigating cholesterol:
Scientists identify genes linked to sitosterolemia; study finds influence of familial traits on response to diet

New platelet receptor identified:
Gene may be potential target for anti-clotting drugs

Researchers identify polymorphisms that influence homocysteine levels

Defenders of the Truth: The Battle for Science in the Sociobiology Debate and Beyond.
By Ullica Segerstråle

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January 5, 2001

Genes, Mother's Milk and Diabesity:
Scientists map genome interactions and detect influence of mother's milk on obesity-induced diabetes

Cell factories slow growth and shrink brain tumors

Microarray technology identifies genes controlled by master switches:
Techniques to be tested on 200 circuits in yeast

The metabolome provides clues to gene function

Production of two proteins encourages spinal cord regeneration

High-throughput profiling of sequence variation in a single gene:
Association between substance dependence and version of µ opioid receptor gene

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